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We are integrating mindfulness into the heart of the healthcare delivery system, by creating a replicable and sustainable model for implementing mindfulness in the Patient-Centered Medical Home (PCMH). PCPs will be offered intensive mindfulness training course followed by training in Mindful Communication. Using a scalable adaptation of Mindfulness-Based Stress Reduction specifically for primary care, PCMH behavioral staff will offer intensive mindfulness training for patients at all primary care sites throughout our culturally and economically diverse community health system. Primary outcomes include patient experience of care, provider experience of caring, patient health outcomes, and illness management and health maintenance behaviors. A healthcare delivery system transformation project demonstrating higher levels of patient-centeredness in primary care, increased PCP well-being, and enhanced patient self-management skills would be innovative and ripe for national dissemination.