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Family history is an essential component of any medical appointment, independently of specialty. Also, a detailed family history can be as informative as genetic testing (if not more!). However, there is a void here for those who do not know their biological relatives or have very little contact with them. Moreover, when performing genetic testing, we frequently inquire about family history and test parental samples in the hope of better interpreting genetic variants. So, will genetic testing (e.g. whole exome sequencing) be beneficial for individuals estranged from their biological families, as it will finally allow them to have a glimpse of basal risk? Or will the many variants of unknown significance overwhelm them (us?) and provide little meaningful/practical/actionable information?