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Couples at risk of having a child with a mitochondrial disease are currently offered 3 parenthood options: conceive naturally and gamble with the risk of having a very sick child, use an egg donor, adopt. Therefore some people argue that mitochondrial donation is not strictly necessary. Should the time, effort and money used for mitochondrial donation be used on trying to find better treatments for mitochondrial diseases instead of being used in the prevention of children being born with them? Or, like many other couples who need assisted reproductive medicine (due to infertility) or preimplantation genetic diagnosis (due to risk of passing a genetic disease to their descendants), mitochondrial donation should be offered as an option to those at risk?