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Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is the most common periodic fever syndrome of childhood. Children with PFAPA present at around 2 years of age with regular monthly fevers associated with tonsillitis, swollen lymph nodes, or canker sores. These frequently recurring fevers create significant disruption in families.

No test exists to confirm the diagnosis of PFAPA; instead, physicians rely on a detailed history and timing of fevers to make the diagnosis. Unfortunately, keeping track of a child's fever is difficult. We are designing an international registry of children with PFAPA to better understand its cause and most effective treatments. We plan to provide participants with wearable thermometers to monitor their fevers. A detailed understanding of fever patterns in PFAPA may help physicians make more rapid and accurate diagnoses. Precisely identifying the onset of fever may also help to provide more effective treatments.