Because data from animal studies do not always reliably predict outcomes in humans, to what extent should babies produced through mitochondrial transfer be enrolled into a prospective study to better understand the impact of the procedure on germline DNA, mitochondrial inheritance patterns, general health, quality of life outcomes, etc? Should such a process be mandatory (mandate the parents to assent), voluntary, or other (presume consent of the baby up until adulthood, at which time he/she can opt out of further data collection)? Would such a procedure obligate future generations as well to be studied prospectively? Alternatively, is it inappropriate to force the acquisition of new knowledge (through a prospective study) with such new procedures?
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