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Joint Submission with Ed Boyer (

Chronic disease prevention and management strategies have long been hindered by the challenge of maintaining appropriate adherence to oral medication regimens. Accurate adherence monitoring can facilitate delivery of support interventions to optimize prevention and treatment outcomes. Current methods for medication adherence have variable precision and reliability. We propose an ingestible biosensor system comprising of 1) a digital pill that emits a unique radio frequency signal upon contact with gastric pH which 2) is collected by a wearable reader that 3) relays ingestion data to a cloud based interface that allows bidirectional patient-physician interaction to improve adherence. Our system achieves maximal stickiness by engaging patients in the design of their own interventions, ensuring that their medication adherence is enduring.