Overall I'm not terribly impressed by the weight loss effects, however, compared with other medical treatments this is actually very good (I think). I'm wondering if the authors/experts think whether there will be maintained long-term effects on weight loss or weight maintenance. The weight loss curves seem to hit maximal effect by 40 weeks in Figure 1A.
Also, where will this new medication fit into practice - especially given that it wasn't as effective in higher BMI patients? Will this be something that patients in the BMI 25.1-30 range will receive? Could this potentially be a therapy that super obese patients receive to decreased their operative risk for a weight loss surgical procedure like a gastric bypass or sleeve gastrectomy?