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In the last question it was brought up that only a minority of patients in the study had pneumococcal and influenza vaccinations. Dr. Pavia provided the CDC statistical data that in adults 19-64 years old with risk factors for severe pneumococcal disease, only 21% had been vaccinated. What insights do you have on the challenges and specific strategies in improving prevention? How do these challenges compare to the more publicized vaccine pushback in the pediatric population?