Over 3 million people in the US with disease-related nerve damage to the bladder must self-catheterize multiple times daily to drain urine. Repeated catheterization results in bladder infections that generate millions of clinic, ER and hospital visits every year costing over $600 million/year. Current treatment is limited to antibiotic therapy whose chronic use can make the culprit bacteria more drug resistant. We have conceptualized a combination photodynamic therapy (PDT)-catheter system that would enable patients to economically prevent or treat these UTIs at home without specialized medical support or the risk of inducing drug resistance. The PDT drugs proposed are a proprietary combination of generic drugs currently in clinical use and the catheter is a modified Foley capable of channeling a drug-activating light dose into the bladder. Treatment would be self-administered and take less than one hour.
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