The causes of cigarette addiction appear to be multi-factorial, including a component of sensineural stimuli. Dr. Adam Leventhal's comment mentioned an interesting 2007 study, also by Donny, where 30 participants were divided into 3 arms: nicotine-containing cigarettes, de-nicotinized cigarettes, and no smoking. Daily de-nicotinized cigarette use declined 1.7 cigarettes/day compared to the preferred brand baseline. De-nicotinized users also had a 31% decline in the number of puffs. However, acute craving suppression following smoking did not differ between the groups. Subjects were followed for 11 days, compared to 6 weeks in the most recent study.
Would a long-term study on a de-nicotinized cigarette use be of interest? How can we account for the non-nicotine related factors in cigarette addiction to develop a strategy to improve this major public health problem? Read the 2007 study here: ncbi.nlm.nih.gov/pubmed/172222...
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