It sounds like most of you are optimistic about the conclusions of the IPERGAY study, demonstrating that perfect daily PrEP adherence is not required for prevention; but I noticed one or two reservations about how this can or should play out in the real world. Let's delve a little deeper into the limitations of the study that came up for you.
What do you wish you could have seen in the study design or analysis? In what ways do you predict the study will translate well into the real world, and in what ways might it not translate? What gaps in knowledge still remain about our understanding of on-demand PrEP?