One obvious difference between daily PrEP and on-demand PrEP is that on-demand PrEP, or even just non-daily PrEP, would require fewer pills thus less expense on the patient, insurance company, or government that is paying.
How cost-effective do you think on-demand PrEP will be in our national/global prevention strategies? Is there a context or rationale by which the benefit of reduced cost would outweigh the risk of lower efficacy or effectiveness (granted that we don't quite know yet the difference)?
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