Given that Teen-LABS is pediatric cohort that is morbidly obese (BMI> 50 on average), aren’t these the types of patients that are higher risk for genetic causes for their obesity? For example, things like MC4R mutations or leptin deficiency? Was there a standardized genetic workup done on these patients prior to inclusion in the study? Could that potentially be confounding the data?
At least from animal models, our experience and others have identified that the efficacy of these procedures can differ significantly depending on the genetic background. As Teen-LABS has confirmed and demonstrated the safety and efficacy of these procedures in pediatric patients, are there (or should there be) guidelines for a standardized genetic workup in these patients?
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