As mentioned by our experts, Mucormycosis is a very difficult diagnosis to make and is often made at autopsy. Few cases of Mucormycosis endocarditis have been reported in the literature.
Risk factors include ketoacidosis, neutropenia, iron overload, iron chelation use (particularly deferoxamine), injection drug use, and immunosuppression.
Mucor thrives in an iron-rich environment. Hence, the deferoxamine-iron conjugate acts as a siderophore and allows the infection to take hold.
Blood cultures and beta-D-glucan are not helpful in making the diagnosis. Tissue culture and silver stain is needed. Attached is the pathologic image from this case which shows the wide, aseptate, ribbon-like fungi with wide-angle branching.
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