Given these variables, two main questions come to mind in envisioning a follow-up study (such as a prospective RCT or a retrospective analysis of an RCT) to confirm the role of CDX2 as a prognostic biomarker in stage II disease.
First, how much sub-stratification based on tumor characteristics (i.e. other molecular markers and clinicopathologic features) is necessary? How much sub-stratification is likely feasible?
Second, how much sub-stratification based on the adjuvant chemotherapy regimen is necessary? Is surgery alone vs. adjuvant chemotherapy an appropriate comparison or should surgery alone be compared to a specific chemotherapy regimen? How much sub-stratification is likely feasible or ethical?
Essentially, in a randomized study to examine the prognostic implications of a CDX2-negative tumor, how would you negotiate the trade-off between increased applicability and decreased sample size?
Easy one-click social registrationIs this safe?
We only receive the minimum information necessary to verify your account. We never get access to your friends/contacts or your profile, and we never post on your behalf. Your social account is used for logging in only.ORRegister via email
Send me updates on this challenge
In order to ensure a fair voting process and to make sure that no one votes more than once, we ask that you register either with a social networking account (easiest, only requires one click) or by registering with your email address (this will require you to click on a verification email that we will send you).
You only need to register once.