Thank you for your work on this study. The results are very helpful to inform decisions related to care pathways for this patient population. In thinking about how to operationalize this information, it is important to consider that in the TMP-SMX group 10-20% (depending on how lost to follow up are categorized) have clinical failure. To me, this stresses the importance of a system that can reliably provide close follow up for these patients. The study was able to provide follow up on day 3-4 and 8-10 which is excellent. I am curious how the authors and others in this discussion are able to set up systems at their institutions to address this need for close follow up.
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