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Lead Moderator

Many thanks for the thoughtful contributions thus far. I'd like to ask a tangential immune system 'logistics' question to get different perspectives.

From the paper’s introduction: “In a recent study of oral immunotherapy to hen's egg white, although children achieved unresponsiveness to egg, the majority reverted to egg allergy one month after cessation of consumption. Similar results have been seen with peanut oral immunotherapy. However, there may be different mechanisms operating in the LEAP intervention, potentially resulting in longer-lasting unresponsiveness to peanut.”

Thus, different mechanisms appear to be at play in oral immunotherapy VS standard ingestion, with respect to development of immune tolerance. Can we provide comment on the different results seen in one method vs the other? Is standard ingestion definitively ‘better’ due to prolonged exposure to the immune environment within the gut?