Question special
Lead Moderator

This paper represents an incredibly important series of studies in terms of understanding best practices for minimizing allergy development.

From the design and oversight section, "...in the LEAP Study 640 high-risk infants were stratified into two groups on the basis of a peanut skin-prick test (0 mm versus a 1 to 4 mm wheal) and then randomized to peanut avoidance or consumption until 60 months of age when peanut allergy was assessed by oral peanut challenge."

Presumably, there was also a third high-risk group - children whose wheal was measured at >4mm. Do the design, results, and/or conclusions of this set of studies also give us insight into how we can address allergy in children with more severe reactions, e.g. in these >4mm children? How much more difficult is it to study a potentially anaphylactic group?