Question special
Lead Moderator

This paper represents an incredibly important series of studies in terms of understanding best practices for minimizing allergy development.

From the design and oversight section, " the LEAP Study 640 high-risk infants were stratified into two groups on the basis of a peanut skin-prick test (0 mm versus a 1 to 4 mm wheal) and then randomized to peanut avoidance or consumption until 60 months of age when peanut allergy was assessed by oral peanut challenge."

Presumably, there was also a third high-risk group - children whose wheal was measured at >4mm. Do the design, results, and/or conclusions of this set of studies also give us insight into how we can address allergy in children with more severe reactions, e.g. in these >4mm children? How much more difficult is it to study a potentially anaphylactic group?