First, I highly estimate and applaud the information provided by the rigorously conducted AKIKI trial.
Continuous RRT was applied in only 30% of the AKIKI patients. It was not specified which AKIKI patients received continuous RRT, what mode was used, and whether continuous RRT was provided at an earlier or later stage of the study. Continuous RRT has not been shown to improve mortality or to ward off dialysis dependency but may be beneficial for patients with severe fluid-overload or unstable cardiogenic/septic shock.I saw that in the supplementary material (provided by the NEJM ), we have the PHRC in french but even there you are not very clear about this very important issue.
Many thanks for clarifying this issue.
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Julian Seifter, MD
Director of Renal Medical Student Education at Harvard Medical School
Sushrut Waikar, MD, MPH
Constantine L. Hampers Distinguished Chair in Renal Medicine at Brigham and Women's Hospital
Kassem Safa, MD
Transplant Nephrologist, Mass General Hospital
Petra Simic, MD
Medicine resident at MGH, Stem cell researcher, future MGH/BWH nephrology fellow
Sagar Nigwekar, MD, MMSc
Assistant in Medicine, Division of Nephrology, Mass General Hospital
Michael Darmon, MD, PhD
Intensivist, Saint-Etienne University Hospital, France
Patrick Honoré, MD, PhD, FCCM
Director of Critical Care Nephrology Platform and Hemofiltration Research at Intensive Care Dept VUB University-UZ Brussels
Tukaram Jamale, MD
Associate Professor, Dept. of Nephrology at Seth GS Medical College and KEM Hospital at Seth GS Medical College and KEM Hospital
Paul Palevsky, MD
Professor of Medicine and Clinical and Translational Science, University of Pittsburgh School of Medicine; Chief of the Renal Section at the VA Pittsburgh Healthcare System at VA Pittsburgh Healthcare System
Suvi Vaara, MD, PhD
Specialist in Anesthesiology and Intensive Care Medicine at University of Helsinki and Helsinki University Hospital
Eric Hoste, MD, PhD
Professor in Medicine and Chief of Clinic, Intensive Care Unit, Ghent University Hospital at Ghent University Hospital
Noel Gibney, MB, FRCP(C)
Intensivist at the University of Alberta Hospital and keen tennis player and fan.
Matthieu Legrand, MD, PhD
Professor in Anesthesiology and Critical Care Medicine at St-Louis Hospital, University Paris Diderot
Sean Bagshaw, MD, MSc
Sean Bagshaw, MD, MSc, Associate Professor in the Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta
Ravindra Mehta, MD
Professor of Medicine in the Division of Nephrology and Associate Chair for Clinical Research in the Department of Medicine at University of California San Diego at UCSD Department of Nephrology
Saber Barbar, MD, PhD
Intensivist in the Anesthesiology and Critical Care Department at Nîmes University Hospital, France at Nîmes University Hospital
Ashita Tolwani, MD
Professor of Medicine in the Division of Nephrology, Associate Director of ICU Nephrology, and Director of the CRRT Program at the University of Alabama at Birmingham (UAB). at University of Alabama at Birmingham
MD/PhD Candidate at Washington University in St. Louis School of Medicine
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