Fantastic findings from this paper. I understand that the patients across the seven case series were not selected based on age, genetic background, and family history. Looking at the race/ethnic background of all the patients put together, it seems that 40/692 (5.8%) patients were Non-Hispanic blacks. Having said that, blacks constitute approximately 10% of the US population (~3% in UK), have higher incidence rates of prostate cancer compared to whites, and have a more aggressive disease course. What are your thoughts on studying germline mutations in DNA-repair genes in the black/AA population with prostate cancer in more detail? The findings may turn out to be applicable more holistically along the spectrum that Dr. Beltran has alluded to. Thanks!
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