Question normal

or was the study open for any men with metastatic prostate cancer, including men who may have initially presented with local disease and had been treated and followed perhaps for years and later developed metastatic prostate cancer, also how was metastatic defined did the study include men who's only site of mets was regional LNs. I am trying to get a better idea of who to send for genetic counseling/testing all metastatic or only de novo presentation of metastatic. Thanks