To our experts: The authors note that one of the study limitations is that the patient population included only young children with mild persistent asthma, and that acetaminophen could still exacerbate asthma in older subjects or those with more severe asthma. What is known about the genetic correlation for pediatric patients in predisposition for asthma? Are there any particular genes related to induction of pain and fever? To our experts, can you speculate on why the study findings might change for older subjects?
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Wanda Phipatanakul, MD, MS
Associate Professor of Pediatrics at Boston Children's Hospital / Harvard Medical School
Ian Paul, MD, MSc
Professor of Pediatrics and Public Health Sciences at Pennsylvania State University College of Medicine
William Sheehan, MD
Instructor of Pediatrics, Harvard Medical School at Boston Children's Hospital
Tzu-Ying Chuang, PhD
MD/PhD candidate at the University of Virginia.
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- Question: Genetics considerations for the study