What if people could see the progression of their health, wellness or disease/disorder trajectories in their own bodies? We have made this experience a virtual reality using a sophisticated high-tech personalized Avatar that incorporates evidence-based predictive analytics that illuminate what could happen if patients engage and adhere to behavioral and/or medical guided recommendations and therapies? Our partners have successfully piloted use of an innovative personalized health coaching program with over 78K participants, resulting in long-term weight loss and prevention of Type II diabetes.
We are now planning to augment our healthcare solution with real-time biomarker-based assessment and biofeedback that is linked to our Avatar technology and accessible via a smart phone-based APP to allow for real-world, ambulatory and ecological monitoring, assessment, therapy, data transmission and periodic (as prescribed) neurocognitive testing using an internet-based and validated assessment battery (>400,000 subject normative database). This will extend our Avatar patient motivation and therapeutic compliance application beyond the realm of diabetes to advance preventive approaches to Cognitive Fitness, especially exercise therapy.
Central to the extension and augmentation of the personalized Avatar component of our protocol is a state-of-the-art biomarker-guided exercise therapy program in which specific heart rate variability (HRV) measures will serve as periodic endpoint outcome measures. SDNN, especially, has emerged as a highly predictive HRV response that has been shown to reflect both cardiologic and mental status. Our own preliminary data has also revealed strong relationships between SDNN and a number of cognitive performance markers that are associated with specific brain structures and functioning that have been implicated in the cognitive fitness and decline equation. An optional protocol component will be structural and functional MRI scans, one at baseline and others at prescribed endpoints.
Consequently, our protocol brings methodological rigor and data-driven accountability to the therapeutic process in user-friendly manner, allowing for the advanced tracking of numerous psychological, psychophysiological and brain functioning variables longitudinally in assessment-diagnostic and intervention efficacy contexts; with the personalized Avatar serving to illuminate the therapeutic journey (time-travel) and associated positive or negative changes pertaining to Cognitive-Fitness.
I. Initial Neurocognitive Assessment with Optional Baseline MRI & fMRI and/or qEEG
• BRC (Internet-based) normative database
• Flagging Deficits:
1 Standard Deviation = Negative 1
2 Std. Dev. = Neg. 2
3 Std. Dev. = Neg. 3
II. Initial Heart Rate Variability Baseline Assessment
SDNN as the Key Biomarker of Cardiologic Status/Physical Fitness and Correlate of Cognitive and Mental Status.
SDNN and other HRV time and frequency domain measures have been found to be differentially associated with cognitive peak performance or deficits, making it a user-friendly predictive biomarker relative to mind-fitness.
III. Creation of Personalized Avatar with Predictive Time Travel Analytics
See image above: Derived from a real-case study of obesity/Type II Diabetes. The Avatar will depict HRV and brain changes over time and visually guide the exercise process and include HRV and EEG changes at endpoints (real and projected).
NOTE: diabetes and obesity and their co-morbidities have been linked to dementia and Alzheimer's and normative cognitive decline and will be further addressed and treated in the context of our overall Cognitive Fitness and preventive Cognitive Decline Protocol that will also target a wide array of medical and psychiatric conditions
IV. Administration of Exercise Protocol:
Sensor Technology Guided
V. Endpoint Analytics:
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